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Clinical Trials

Now that insight into the disease mechanisms and clinical disease course of Vanishing White Matter (VWM) have improved over the past decade, worldwide efforts focus on treatment opportunities for VWM. This page lists the current clinical trials for VWM.

Current Trial

Guanabenz trial for VWM

The Amsterdam Leukodystrophy Center at the Amsterdam University Medical Centers (Amsterdam UMC) is conducting a clinical trial in children with Vanishing White Matter (VWM). In this trial, they want to evaluate whether a drug called Guanabenz is effective in slowing progression, stabilizing, or even improving the brain white matter abnormalities in VWM. Guanabenz is an old and well-known medicine that has been used for decades for the treatment of high blood pressure. It has been approved by the FDA, the American medicines agency.

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More is coming soon…

This overview will continuously be updated with the latest clinical trials. As soon as clinical trials with new treatment options for VWM are initiated, the studies will be listed on this page.