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Astrocyte Subtype Vulnerability in Stem Cell Models of Vanishing White Matter
November, 2019
Leferink PS, Dooves S, Hillen AEJ, Watanabe K, Jacobs G, Gasparotto L, Cornelissen-Steijger P, van der Knaap MS, Heine VM
Ann Neurol; 86(5):780-792. doi: 10.1002/ana.25585. Epub 2019 Sep 10. PMID: 31433864; PMCID: PMC6856690.
Affected astrocytes in the spinal cord of the leukodystrophy vanishing white matter
April, 2018
Leferink PS, Breeuwsma N, Bugiani M, van der Knaap MS, Heine VM
Glia; 66(4):862-873. doi: 10.1002/glia.23289. Epub 2017 Dec 29. PMID: 29285798; PMCID: PMC5838785.
Astrocytes are central in the pathomechanisms of vanishing white matter
April 1, 2016
Dooves S, Bugiani M, Postma NL, Polder E, Land N, Horan ST, van Deijk AL, van de Kreeke A, Jacobs G, Vuong C, Klooster J, Kamermans M, Wortel J, Loos M, Wisse LE, Scheper GC, Abbink TE, Heine VM, van der Knaap MS
J Clin Invest; 126(4):1512-24. doi: 10.1172/JCI83908. Epub 2016 Mar 14. PMID: 26974157; PMCID: PMC4811153.
Leukoencephalopathy with vanishing white matter: a review
October, 2010
Bugiani M, Boor I, Powers JM, Scheper GC, van der Knaap MS
J Neuropathol Exp Neurol; 69(10):987-96. doi: 10.1097/NEN.0b013e3181f2eafa. PMID: 20838246.
Natural History of Vanishing White Matter
August 2018
Hamilton EMC, van der Lei HDW, Vermeulen G, Gerver JAM, Lourenço CM, Naidu S, Mierzewska H, Gemke RJBJ, de Vet HCW, Uitdehaag BMJ, Lissenberg-Witte BI; VWM Research Group, van der Knaap MS
Ann Neurol; 84(2):274-288. doi: 10.1002/ana.25287. Epub 2018 Sep 6. PMID: 30014503; PMCID: PMC6175238.
Cell Replacement Therapy Improves Pathological Hallmarks in a Mouse Model of Leukodystrophy Vanishing White Matter
March 5, 2019
Dooves S, Leferink PS, Krabbenborg S, Breeuwsma N, Bots S, Hillen AEJ, Jacobs G, van der Knaap MS, Heine VM.
Stem Cell Reports; 12(3):441-450. doi: 10.1016/j.stemcr.2019.01.018. Epub 2019 Feb 21. PMID: 30799272; PMCID: PMC6411482.
Bergmann glia translocation: a new disease marker for vanishing white matter identifies therapeutic effects of Guanabenz treatment
June 2018
Dooves S, Bugiani M, Wisse LE, Abbink TEM, van der Knaap MS, Heine VM.
Neuropathol Appl Neurobiol; 44(4):391-403. doi: 10.1111/nan.12411. Epub 2017 Aug 1. PMID: 28953319.
eIF2B activator prevents neurological defects caused by a chronic integrated stress response
January 9, 2019
Wong YL, LeBon L, Basso AM, Kohlhaas KL, Nikkel AL, Robb HM, Donnelly-Roberts DL, Prakash J, Swensen AM, Rubinstein ND, Krishnan S, McAllister FE, Haste NV, O'Brien JJ, Roy M, Ireland A, Frost JM, Shi L, Riedmaier S, Martin K, Dart MJ, Sidrauski C.
8:e42940. doi: 10.7554/eLife.42940. PMID: 30624206; PMCID: PMC6326728.
The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes
February 28, 2018
Wong YL, LeBon L, Edalji R, Lim HB, Sun C, Sidrauski C.
7:e32733. doi: 10.7554/eLife.32733. PMID: 29489452; PMCID: PMC5829914.
Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy
September 18, 2018
Atzmon A, Herrero M, Sharet-Eshed R, Gilad Y, Senderowitz H, Elroy-Stein O.
Front Mol Neurosci. 2018;11:336. Published 2018 Sep 18. doi:10.3389/fnmol.2018.00336